Today the pressures in productive gas collectors on the Dnieper-Donets rift are considerably lower than hydrostatic ones. Opening such formations while drilling is a challenging task in terms of preventing losses and differential pressures. In order to solve the problem, one needs to improve the methods of effective temporary colmation of productive formations with acid-soluble materials under the conditions of abnormally low formation pressures during drilling on fields with late terms of development. Traditional algorithms of lost circulation control in abnormally low reservoir pressure, developed by leading world services companies, often turn out to be unworkable. In order to conduct the lost circulation control, one often chooses colmatants, which totally align with the principles of ideal packaging, however do not meet the criterion of strength or resistance to significant differential pressure. As a result, in the course of the subsequent drilling there can be another circulation loss in already colmated layer. In Ukraine the lost circulation control sphere is being developed by means of selecting colmatants according to a new principle. The article has proposed the activities for the lost circulation curing and pollution reducing of productive collectors. For this purpose the generalized characteristic-criterion of colmatants has been developed and used. The criterion got a name “flexibility”, i.e. a deformation, compaction and penetration (into porous-fissured medium) capability under immense pressure. With the help of the criterion the set of particular colmatant have been chosen; also, principles of colmatant mixtures selection under the relevant geological and mining conditions have been identified. In many cases, there is no need to calculate the physical parameters of the formation and the circulation loss crack due to flexibility of colmatant; one only has to select the optimal concentrations of materials and the periodicity of input these materials to the mud. The developed technology confirms the need to improve the algorithms for circulation loss prevention and curing, primarily for conditions of abnormally low reservoir pressures