Creating safe working conditions is the main task of the state in the implementation of the constitutional right of citizens. The task of state policy in the field of labor protection is to reduce the level of injuries and occupational diseases at work. Occupational safety is one of the basic principles of the oil and gas industry. Particular attention is paid to the continuous improvement of health and safety standards. This reduces the risk of accidents and possible negative consequences for the environment. Now the focus of the organization is not only labour protection, but its broader interpretation, which is presented in the following three aspects: safety, health and psychosocial component of employee well-being. The aim of the work is to analyze the causes of injuries at workplace to form a sustainable culture of safety and health of workers. To achieve this goal it is necessary to solve the following tasks: analysis of the causes of accidents and occupational injuries at the enterprises of the oil and gas complex; creating a sustainable culture of safety and health of employees. A detailed analysis of accidents that occurred at the oil and gas industry enterprises during 2014 – 2019 is analyzed. The change of the coefficient of the frequency of injuries is analyzed. The analysis of the causes of industrial injuries is given. There is a tendency to increase accidents related to organizational reasons. Psychophysiological causes also affect a significant number of accidents. The distribution of events by potential danger will help properly allocate the organization's resources to achieve the desired results in the field of labor protection. The methodology for assessing the level of workplace safety is Stevens' psychophysical law to predict the likelihood of harm to the health of workers in the process of labor activity. An integrated approach has been created, combining analysis, assessment and risk management on the model of continuous process improvement (Deming cycle), the implementation of which should lead to zero mortality, zero loss of time from accidents, zero injuries, zero damage to nature. Setting goals to be achieved in the field of security involves the formation of a strategic program to identify the main practical steps. The program approach makes it possible to step by step monitor and guide the actions of all stakeholders to form a sustainable culture of safety and health of workers at workplace